Vascular endothelium: pharmacologic and genetic manipulations
نویسندگان
چکیده
منابع مشابه
Malaria and Vascular Endothelium
Involvement of the cardiovascular system in patients with infectious and parasitic diseases can result from both intrinsic mechanisms of the disease and drug intervention. Malaria is an example, considering that the endothelial injury by Plasmodium-infected erythrocytes can cause circulatory disorders. This is a literature review aimed at discussing the relationship between malaria and endothel...
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Aging is a biological process that causes a progressive deterioration of structure and func‐ tion of all organs over the time [1]. According to the United Nation’s report, the number of people aged 60 and over in the world has increased from 8% (200 million) in 1950 to 11% (760 million) in 2005, and it is estimated that this number will further increase to 22% (2 bil‐ lion) in 2050. It is expec...
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To determine the shear force acting on a white blood cell sticking to the endothelium of a blood vessel, the flow field about a single white blood cell in a venule was determined by high-speed motion picture photomicrography. The force acting on the white blood cell was then calculated according to the principles of fluid mechanics. In this paper, the calculation was made using an experimentall...
متن کاملGenetic and Pharmacologic Inhibition of the Chemokine Receptor CXCR2 Prevents Experimental Hypertension and Vascular Dysfunction
BACKGROUND The recruitment of leukocytes to the vascular wall is a key step in hypertension development. Chemokine receptor CXCR2 mediates inflammatory cell chemotaxis in several diseases. However, the role of CXCR2 in hypertension development and the underlying mechanisms remain unknown. METHODS Angiotensin II (490 ng·kg-1·min-1) or deoxycorticosterone acetate (DOCA) salt-induced mouse hyper...
متن کاملThe Vascular Endothelium in Diabetes
Key Points • The endothelium is a key participant in the homeostasis of the vessel wall. • Nitric oxide (NO) plays a key role in regulating healthy vascular function. • Reduced local NO bioavailability is a characteristic hallmark of vascular endothelial dysfunction. • Endothelial dysfunction is chiefly driven by oxidative stress and inflammation. • A number of techniques for assessing endothel...
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ژورنال
عنوان ژورنال: Journal of Vascular Surgery
سال: 1998
ISSN: 0741-5214
DOI: 10.1016/s0741-5214(98)70122-3